Friday, November 6, 2009

Phenol: CNS toxin, causes comas and death, used in vaccinations

Phenol: nephrotoxic; CNS toxin, heart toxin, gastrointestinal, kidney, lung and blood vessel toxin... the Nazi's used it in Auschwitz to exterminate people, if that leaves you any indicator of it's toxicity.

Centers for Disease Control information on Phenol:

Phenol is well absorbed by all routes of exposure. Exposure by any route can cause systemic effects.

Skin/Eye Contact

All forms of phenol cause irritation, and acute toxic effects of phenol most often occur by skin contact. Even dilute solutions (1% to 2%) may cause severe burns if contact is prolonged. Systemic toxicity can result from skin or eye exposures. Phenol vapor and liquid penetrate the skin with an absorption efficiency approximately equal to the absorption efficiency by inhalation. In one case, death occurred within 30 minutes after skin contact.

(yet we inject this directly into the bloodstream of infants.)

Children are more vulnerable to toxicants absorbed through the skin because of their relatively larger surface area:body weight ratio.


Accidental and intentional ingestions of phenol have been reported. As little as 50 to 500 mg has been fatal in infants. Deaths in adults have resulted after ingestions of 1 to 32 g.

Phenol has anesthetic properties. It is also used in the production of drugs, weedkillers, and synthetic resin. Exposure of the skin to concentrated phenol solutions causes chemical burns which may be severe. Phenol was also used as a mean of extermination by the Nazis during the Second World War. Phenol injections were given to thousands of people in concentration camps, especially at Auschwitz-Birkenau. --

EDF Suspected - cardiovascular or blood toxicant, developmental toxicant, gastrointestinal or liver toxicant, kidney toxicant, neurotoxicant, reproductive toxicant, respiratory toxicant, skin or sense organ toxicant. More hazardous than most chemicals in 4 out of 12 ranking systems. On at least 8 federal regulatory lists.

HUMAN TOXICITY: Phenol is toxic with a probable oral lethal dose to humans of 50-500 mg/kg. Some individuals may be hypersensitive with lethality or serious effects at very low exposures. Rapid absorption and severe systemic toxicity can occur after any route of exposure including skin. Death and severe toxicity are usually due to effects on the CNS, heart, blood vessels, lung, and kidneys. However, toxic manifestations may vary somewhat with the route. Observed effects from acute exposure may include: shock, delirium, coma, pulmonary distress, phenolic breath, scanty/dark urine, and death. Protracted or chronic exposure usually results in major damage to the liver, kidneys and eyes. Pigmentary changes of the skin have been noted. Consumption of water contaminated with phenol resulted in diarrhea, mouth sores, burning of the mouth, and dark urine. Phenol is highly caustic to tissues. Skin exposure results in pain, then numbness, blanching, severe burns, and eschar formation. Ingestion leads to burning of throat and severe gastrointestinal inflammation. Inhalation can result in pulmonary irritation and edema.

Phenol is nephrotoxic to humans and animals, especially following chronic exposure. ... Humans have experienced nephritis following toxic dermal exposure. [Sullivan, J.B. Jr., G.R. Krieger (eds.). Hazardous Materials Toxicology-Clinical Principles of Environmental Health. Baltimore, MD: Williams and Wilkins, 1992., p. 1095]

Phenol is toxic if absorbed and may result in death even if the exposed area is as small as that of a hand or forearm. [Kirk-Othmer Encyclopedia of Chemical Technology. 3rd ed., Volumes 1-26. New York, NY: John Wiley and Sons, 1978-1984., p. V17 381 (1982)]

Application of moderate amounts to the skin causes epidermal separation and a severe exposure causes necrosis. [Gilman, A.G., L.S.Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 7th ed. New York: Macmillan Publishing Co., Inc., 1985., p. 969]

Topical exposure to phenol results in brown, relatively painless patches on the skin and whitish patches on the mucous membranes. Ingestion results in gastrointestinal symptoms that range from nausea, vomiting, diarrhea, and abdominal pain to hematemesis and hematochezia. Inhalation or aspiration produces coughing, stridor, and an aromatic odor of the breath. Systemic complaints from acute exposure include CNS stimulation and depression, seizures, coma, tachycardia, ventricular dysrhythmias, hypotension, hypothermia, metabolic acidosis, and acute tubular necrosis. [Ford MD, Delaney KA, Ling LJ, Erickson T; Clinical Toxicology. W.B. Saunders Company., Philadelphia, PA. 2001, p. 752]

Effects on humans. A wide range of adverse effects has been reported following well-documented human exposure to phenol by the dermal, oral or intravenous routes.

Gastrointestinal irritation has been reported following ingestion. Local effects following dermal exposure range from painless blanching or erythema to corrosion and deep necrosis. Systemic effects include cardiac dysrhythmias, metabolic acidosis, hyperventilation, respiratory distress, acute renal failure, renal damage, dark urine, methaemoglobinaemia, neurological effects (including convulsions), cardiovascular shock, coma and death. The lowest reported dose resulting in a human death was 4.8 g by ingestion; death occurred within 10 min.

The potential for poisoning through inhalation of phenol vapours has long been recognized, but no cases of death following this route of exposure have been reported.


(this is written on the International Chemical Safety Card for Phenol!)

Skin EASILY ABSORBED. Serious skin burns. Numbness. Convulsion. Collapse. Coma. Death.

Ingestion Corrosive. Abdominal pain. Convulsions. Diarrhoea. Shock or collapse. Sore throat. Smoky greenish-dark urine.


Phenol and its vapor are corrosive to the eyes, the skin and the respiratory tract.[14] Repeated or prolonged skin contact with phenol may cause dermatitis, or even second and third-degree burns due to phenol's caustic and defatting properties.[15] Inhalation of phenol vapor may cause lung edema.[14] The substance may cause harmful effects on the central nervous system and heart, resulting in dysrhythmia, seizures, and coma.[16] The kidneys may be affected as well. Exposure may result in death and the effects may be delayed. Long-term or repeated exposure of the substance may have harmful effects on the liver and kidneys."[17] The substance is a suspected carcinogen. Besides its hydrophobic effects, another mechanism for the toxicity of phenol may be the formation of phenoxyl radicals.[18]

14 ^ a b Budavari, S, ed (1996). The Merck Index: An Encyclopedia of Chemical, Drugs, and Biologicals. Whitehouse Station, NJ: Merck.
^ Lin TM, Lee SS, Lai CS, Lin SD (Jun 2006). "Phenol burn". Burns: Journal Of The International Society For Burn Injuries 32 (4): 517-21. PMID 16621299.
^ Warner, MA; Harper, JV (1985). "Cardiac dysrhythmias associated with chemical peeling with phenol". Anesthesiology 62: 366–7.
^ World Health Organization/International Labour Organization: International Chemical Safety Cards,
^ Hanscha, Corwin; McKarnsb, Susan C; Smith, Carr J; Doolittle, David J (15 June 2000). "Comparative QSAR evidence for a free-radical mechanism of phenol-induced toxicity". Chemico-Biological Interactions 127 (1): 61-72.

Further studies on phenol toxicity

Cynthia D. Selassie*, Tushini V. DeSoyza, Phenol toxicity in leukemia cells: a radical process? Chemico-Biological Interactions Volume 113, Issue 3, 5 June 1998, Pages 175-190

Corwin Hanscha, Susan C. McKarnsb, Comparative QSAR evidence for a free-radical mechanism of phenol-induced toxicity; Chemico-Biological InteractionsVolume 127, Issue 1, 15 June 2000, Pages 61-72

Mark T. D. Cronin and T. Wayne Schultz, Structure-toxicity relationships for phenols to Tetrahymena pyriformis, Chemosphere Volume 32, Issue 8, April 1996, Pages 1453-1468

Tatjana Tišler and Jana Zagorc-Končan, Comparative assessment of toxicity of phenol, formaldehyde, and industrial wastewater, Water Air and Soil Pollution; Volume 97, Numbers 3-4 / July, 1997

P. J. D Foxall, M.R. Bending, Acute Renal Failure Following Accidental Cutaneous Absorption of Phenol: Application of NMR Urinalysis to Monitor the Disease Process Human & Experimental Toxicology, Vol. 8, No. 6, 491-496 (1989)

Serrine S. Lau, Quinone-Thioether-Mediated Nephrotoxicity, Drug metabolism reviews, 1995, Vol. 27, No. 1-2, Pages 125-141

Excerpt: These data suggested a role for GSH conjugation in 4-amino- phenolnephrotoxicity

Chan TY, Critchley JA. Is chloroxylenol nephrotoxic like phenol? A study of patients with DETTOL poisoning, Vet Hum Toxicol. 1994 Jun;36(3):250-1

Henry A. Spiller, Debra A. Quadrani-Kushner; A Five Year Evaluation of Acute Exposures to Phenol Disinfectant, Clinical Toxicology, 1993, Vol. 31, No. 2, Pages 307-313

Soares ER, Tift JP; Phenol poisoning: three fatal cases, Journal of Forensic Scientists, 1982, Volume 27, issue 3, pages 729-731

Excerpt: Death appeared to be the result of central nervous system toxicity and respiratory failure, the common autopsy finding being pulmonary edema.

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